Get Alkaloids: v. 3: Chemistry and Pharmacology PDF

By R.H.F Manske, H.L. Holmes

ISBN-10: 0080865275

ISBN-13: 9780080865270

ISBN-10: 0124695035

ISBN-13: 9780124695030

Show description

Read Online or Download Alkaloids: v. 3: Chemistry and Pharmacology PDF

Similar chemistry books

Franziska Sprecher's Medizinische Forschung mit Kindern und Jugendlichen: nach PDF

Die Arbeit behandelt die rechtlichen Grundlagen der medizinischen Forschung mit Kindern und Jugendlichen. Dargestellt werden die faktischen und rechtlichen Rahmenbedingungen der medizinischen Forschung mit Minderj? hrigen. Das Buch liefert zudem eine aktuelle ? bersicht ? ber die auf die Humanforschung anwendbaren Normen des schweizerischen, deutschen, europ?

Possible Long-Term Health Effects of Short-Term Exposure To by PDF

The venture that's the topic of this document was once licensed via the Governing Board of the nationwide learn Council, whose individuals are drawn from the Councils of the nationwide Academy of Sciences, the nationwide Academy of Engineering, and the Institute of drugs The participants of the committee liable for the file have been selected for his or her detailed competences and with reference for applicable stability.

Extra resources for Alkaloids: v. 3: Chemistry and Pharmacology

Sample text

Hydrolysis and decarboxylation of the resulting substituted malonate afforded tetrahydropyranyl-4-aceticacid (CLIV). Bouveault OS0,CJI' CHsCOOH 6 - 0 -0 CLII CLV CLIII CLVI CLIV CLVII reduction of this material (as the ester) followed by treatment with fuming hydrobromic acid furnished 3-(2-bromoethyl)-l,5-dibromopen- 40 RICHARD B. TURNER AND R. B. WOODWARD tane (CLVI), which was converted into quinuclidine (CLVII) by the action of ammonia in methanol. Various modificationa of this procedure were also successfully pursued.

The key stage of the final effort was the preparation of dl-homocincholoipon in sufficient quantity for resolution, which was oarried out through the &-tartrates of the corresponding ethyl ester. The d t i n g (+)-homocincholoipon ester was converted into dihydroquinotoxine, and thence, by way of the C-bromo derivative, into dihydroquinidinone. 48 RICHARD B. TURNER AND R. B. WOODWARD Catalytic hydrogenation of the carbonyl group in the presence of palladium gave dihydroquinine, identical in all respects with the naturally occurring alkaloid.

9 would be transformable to geometrically isomeric anhydro compounds (cf. Section 11, 1, b). In fact, possibly for steric reasons, only one product is ordinarily obtained; the isolation of an anhydro base isomeric g t h dihydrocinchene has been reported, but the product was impure and incompletely characterized (97). 4. DIRECTINTERCONVERSIONS When quinine is subjected to the action of potassium hydroxide in hot amyl alcohol, a mixture of the four stereoisomeric bases, quinine, epiquinine, quinidine and epiquinidine, is obtained (168,169).

Download PDF sample

Alkaloids: v. 3: Chemistry and Pharmacology by R.H.F Manske, H.L. Holmes

by George

Rated 4.97 of 5 – based on 19 votes