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These criteria, Koch’s postulates, are still applied in the identiﬁcation of pathogens that can be propagated in the laboratory and tested in an appropriate animal model. The postulates are as follows. • The organism must be regularly associated with the disease and its characteristic lesions. • The organism must be isolated from the diseased host and grown in culture. • The disease must be reproduced when a pure culture of the organism is introduced into a healthy, susceptible host. • The same organism must be reisolated from the experimentally infected host.
Classiﬁcation reﬁnements can therefore be expected to continue in the future. The ICTV report also includes descriptions of subviral agents (satellites, viroids, and prions) and a list of viruses for which information is still insufﬁcient to make assignments. Satellites are composed of nucleic acid molecules that depend for their multiplication on coinfection of a host cell with a helper virus. However, they are not related to this helper. , hepatitis delta virus is a satellite virus). Several years ago, the bacterial virologists who were members of the ICTV agreed to coin similar Latinized family names for the different types of bacteriophages.
Discovery of Viruses The ﬁrst report of a pathogenic agent smaller than any known bacterium appeared in 1892. The Russian scientist Dimitrii Ivanovsky observed that the causative agent of tobacco mosaic disease was not retained by the unglazed porcelain ﬁlters used at that time to remove bacteria from extracts and culture media (Fig. 6). Six years later in Foundations A B D C 11 Berkefeld filter Manometer Backflow trap Sampling chamber Berkefeld filters have three grades of porosities, two of which hold back all bacteria.
A color atlas of Complete Denture Fabrication